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Prostate cancer genetic testing

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Download the ProstateGene brochure

 

The following genes are tested:

Gene

Condition

Lifetime risk of
prostate cancer

BRCA1

HBOC

 1.8 times gen population

BRCA2

HBOC

2-5 times gen pop

HOXB13

Prostate cancer

33 - 60%

MLH1

Lynch syndrome

18% - 30%

MSH2

MSH6

PMS2

EPCAM

Prostate cancer is the most common cancer among men in the UK. Unfortunately, 1 in 8 men will be diagnosed with prostate cancer, with 75% being diagnosed over the age of 65. This means that men have a 12.5% lifetime risk of prostate cancer. The majority of prostate cancer occurs by chance however approximately 5-9% of prostate cancer is estimated to be hereditary and 25% is familial.

What are the signs of hereditary prostate cancer?

You may be at increased risk of prostate cancer if you have any of the following signs in your family:

  • Early onset prostate cancer (diagnosis before age 55)
  • 3 first degree relatives (brother, son, father) diagnosed with prostate cancer
  • Relatives with prostate cancer in 3 successive generations
  • Ashkenazi Jewish ancestry and breast, ovarian or prostate cancer
  • Several relatives with breast cancer, particularly early onset (before age 50)
  • Male breast cancer or ovarian cancer or bilateral breast cancer
  • Early onset bowel or womb cancer (before 50)
  • Several relatives with colorectal or womb cancer at any age

ProstateGene – prostate cancer genetic testing

ProstateGene is a genetic test which analyses the DNA code for 8 different genes which are known to cause an increased risk of prostate cancer. It is performed on a saliva sample and if possible it is always more informative to test a relative who has had prostate cancer.

A genetic counsellor can give you more information about the genes included on the ProstateGene panel.

What can I do if I am shown to be at increased risk?

If you have a mutation this means that you have an increased risk of prostate cancer and possibly other cancers. Your exact risks will depend on which gene mutation has been found. Extra screening and/or risk-reducing strategies will be discussed. It will also be possible to offer predictive testing to other people in your family to see if they also have a mutation.

Screening

Screening aims to diagnose prostate cancers at an earlier more treatable stage however screening for prostate cancer is still imprecise and, in some situations, may lead to unnecessary biopsies or false reassurance.

Two thirds of men with a raised PSA test will not have cancer. Recent research has shown that other biomarkers can improve the accuracy of the PSA test and this method of screening is offered by ProstateHealthUK.

Screening for other cancers may also be needed and will be discussed if necessary.

Genetic counselling

Only 5-9% of prostate cancer is hereditary but if there is a family history of prostate cancer, this can be a big worry. Deciding to have a genetic test is a big decision for any man or woman and one that needs careful consideration. That’s why at ProstateHealth UK we offer genetic counsellors to assist you prior to any testing. Our counsellors will provide you with all the information you need to make a decision and will help explain the process of genetic testing to you. Our counsellors will also be available once you have had your testing to discuss your results and options.

Why would I want to know that I’m at risk of cancer?

Genetic testing can help determine the risk of cancer within a family and guide appropriate cancer screening. Depending on the specific genetic risk different screening tests can be arranged and risk-reducing strategies considered.

Risk factors

It is known that ethnicity influences the risk of prostate cancer: black men have the highest risk of prostate cancer, then white men and Asian men have the lowest risk.

Height is also associated with prostate cancer: the taller a man the higher his risk.

A personal history of some types of cancer (kidney, bladder, melanoma, lung, thyroid) also increases the risk of prostate cancer as does exposure to radiation.

Warfarin, Acetaminophen and diabetes have been shown to lower the risk of prostate cancer.

Lycopenes (from tomatoes and tomato based products) lower the risk of prostate cancer, whilst diets high in calcium may increase the risk.

Price

At GeneHealth UK we offer genetic counsellors to assist you prior to any testing. Our counsellors will provide you with all the information you need to make a decision and will help explain the process of genetic testing to you. Our counsellors will also be available once you have had your testing to discuss your results and options.

The cost for our ProstateGene genetic prostate cancer test is £1500 which includes before and after test counselling.

For more information please contact us.

ProstateGene
If you are worried about prostate cancer due to your father or grand father being diagnosed with it click the icon above
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